As biotechnologies improve, coupled with falling costs, more and more genomic data becomes available fostering a renewed interest in understanding recombinational dynamics at unprecedented levels. In this paper, we survey the field for established as well as exploratory methods for handling the challenging task of untangling recombinations in observed data. These include ways to measure the effects of recombinations as well as infer the recombination events (crossover) themselves. We next track the progress made in model (or phylogeny) based approaches as they have the potential for ushering in the recombinome, the set of all the crossover points along the chromosome in a given organism.
By: Asif Javed; Laxmi Parida
Published in: RC25010 in 2010
LIMITED DISTRIBUTION NOTICE:
This Research Report is available. This report has been submitted for publication outside of IBM and will probably be copyrighted if accepted for publication. It has been issued as a Research Report for early dissemination of its contents. In view of the transfer of copyright to the outside publisher, its distribution outside of IBM prior to publication should be limited to peer communications and specific requests. After outside publication, requests should be filled only by reprints or legally obtained copies of the article (e.g., payment of royalties). I have read and understand this notice and am a member of the scientific community outside or inside of IBM seeking a single copy only.
Questions about this service can be mailed to reports@us.ibm.com .