The rapid publication of important research in the biomedical literature makes it increasingly difficult for researchers to keep current with significant work in their area of interest. This paper reports a scalable method for the discovery of protein-protein interactions in Medline abstracts, using a combination of text analytics, statistical analysis and a set of easily implemented rules. Using a collection of 564 abstracts describing protein interactions, a precision of 0.92 and a recall on 0.84 were obtained. Applying similar techniques to 12,300 abstracts, a precision of 0.61 and a recall of 0.90 were obtained, (f = 0.72) and when allowing for two-hop and three-hop relations discovered by graphical analysis, the precision could be extended to 0.82.
By: James W. Cooper, Aaron Kershenbaum
Published in: RC23278 in 2004
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