A PQ Tree-based Framework for Reconstructing Common Ancestors under Inversions and Translocations

Various international efforts are underway to catalog the genomic similarities and variations in the human population. Some key discoveries such as inversions and translocations within the members of the species have been made in the last few years. The task of constructing a correct genealogy tree of the members of the same species, given this knowledge and data, is an important problem. In this context, a key observation is that the "distance" between two members, or member and ancestor, within the species is small. In this paper, we pose the tree (genealogy) reconstruction problem exploiting some of these peculiarities. Our proposed scheme is based on the idea of minimal consensus PQ trees on permutations. We give a simple scheme to construct the tree and use a modified PQ tree structure to reconstruct the common ancestors on the genealogy tree.

By: Laxmi Parida

Published in: RC23837 in 2005


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