In this report we present the results of the recombinational analysis based on our model IRiS. We investigate HapMap III database with 11 populations and over 1000 samples: we picked this testbed primarily due to the choice of SNPs in the database. In an effort to reduce the effects of compounding errors due to limitations of current technologies and techniques, we focus on the recombining X Chromosome. In our preliminary analysis, our results are two-fold. Firstly, we demonstrate the presence of recombinations-based evidence in short segments of the genome to detect subcontinental divide in the populations. We observe this in both populations-centered as well as recombinations-centered analysis. Secondly, we make the surprising observation that the effect of the population dynamics that shapes the allele-frequency variations between populations is also reflected in the purely recombination-based variations. We conclude that our recombinational-based exploration has the potential to go well beyond the known into non-traditional territories.
By: Laxmi Parida; Asif Javed; Marta Melé; Jaume Bertranpetit
Published in: RC24677 in 2008
LIMITED DISTRIBUTION NOTICE:
This Research Report is available. This report has been submitted for publication outside of IBM and will probably be copyrighted if accepted for publication. It has been issued as a Research Report for early dissemination of its contents. In view of the transfer of copyright to the outside publisher, its distribution outside of IBM prior to publication should be limited to peer communications and specific requests. After outside publication, requests should be filled only by reprints or legally obtained copies of the article (e.g., payment of royalties). I have read and understand this notice and am a member of the scientific community outside or inside of IBM seeking a single copy only.
Questions about this service can be mailed to reports@us.ibm.com .