Making the Most of It: Pathway Reconstruction and Integrative Simulation Using the Data at Hand

Pathway reconstruction is a fundamental task in systems biology toward an ultimate goal of full scale in silico simulations. The data for such reconstructions is mostly lacking, but collection is underway for some model organisms. However, biological specificity may limit the ability to extrapolate findings. High throughput data and methods may alleviate these problems, but only coarse or limited reconstructions are now possible. Inclusion of multiple data sources may improve the situation but remains a challenge.

By: J. Jeremy Rice, Gustavo Stolovitzky

Published in: RC23104 in 2004


This Research Report is available. This report has been submitted for publication outside of IBM and will probably be copyrighted if accepted for publication. It has been issued as a Research Report for early dissemination of its contents. In view of the transfer of copyright to the outside publisher, its distribution outside of IBM prior to publication should be limited to peer communications and specific requests. After outside publication, requests should be filled only by reprints or legally obtained copies of the article (e.g., payment of royalties). I have read and understand this notice and am a member of the scientific community outside or inside of IBM seeking a single copy only.


Questions about this service can be mailed to .